About the Event

Each year the winners of the Warren Alpert Foundation Prize are recognized at a scientific symposium hosted by Harvard Medical School.

Human Genetics and Disease Discovery

2013 Warren Alpert Foundation Prize Scientific Symposium
Thursday, October 3

In honor of David Botstein, PhD, Ronald W. Davis PhD, and David S. Hogness, PhD for their seminal contributions to the concepts and methods of creating a genetic map in the human, and of positional cloning, leading to the identification of thousands of human disease genes and ushering in the era of human genetics.

SYMPOSIUM PROGRAM

Opening Remarks

Jeffrey S. Flier, MD
Dean of the Faculty of Medicine, Harvard University

Moderated by

Stephen Elledge, PhD
Gregor Mendel Professor of Genetics and Medicine, Harvard Medical School and Brigham and Women’s Hospital
Investigator, Howard Hughes Medical Institute

Fred Winston, PhD
John Emory Andrus Professor of Genetics, Harvard Medical School

Remarks and Reflections

Ronald W. Davis, PhD
Professor of Biochemistry and Genetics; Director, Stanford Genome Technology Center, Stanford University School of Medicine

David Botstein, PhD
Anthony B. Evnin Professor of Genomics, Princeton University

Invited Speakers

Where Is the Rest of the Human Genome?
Steven McCarroll, PhD

Assistant Professor, Department of Genetics, Harvard Medical School
Director of Genetics, Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard

Human Genetic Variation and Common Disease
David Altshuler, MD, PhD

Professor of Genetics and of Medicine, Harvard Medical School and Massachusetts General Hospital
Deputy Director and Chief Academic Officer, The Broad Institute of MIT and Harvard

Rare Variants, Therapeutic Targets, and the Future of Medicine
Richard P. Lifton, MD, PhD

Sterling Professor and Chair, Department of Genetics; Professor of Genetics,
Internal Medicine & Molecular Biophysics & Biochemistry, Yale University School of Medicine
Investigator, Howard Hughes Medical Institute

2012 Prize Symposium

Therapeutic Targeting of the Proteasome in Disease

Opening Remarks
Jeffrey S. Flier, MD, Dean of the Faculty of Medicine, Harvard University

Joan S. Brugge, PhD, Louise Foote Pfeiffer Professor of Cell Biology and Chair of the Department of Cell Biology, Harvard Medical School

Award Lectures

These individuals were honored for their discovery, preclinical and clinical development of Bortezomib (Velcade) to FDA approval and front line therapy for the treatment of patients with multiple myeloma.

Alfred L. Goldberg, PhD, Professor of Cell Biology, Harvard Medical School
Functions of the Proteasome: From Protein Degradation to Drug Development

Julian Adams, PhD, President, Research and Development, Infinity Pharmaceuticals
The Discovery and Development of Bortezomib

Kenneth C. Anderson, MD, Kraft Family Professor of Medicine, Harvard Medical School, Director of the LeBow Institute for Myeloma Therapeutics and Director of the Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute
Bench to Bedside Translation of Proteasome Inhibitor Therapy in Multiple Myeloma

Paul G. Richardson, MD, Associate Professor of Medicine, Harvard Medical School and Clinical Director of the Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute
The Clinical Development of Bortezomib in Multiple Myeloma: from Single Agent to Combinations and Beyond

2011 Prize Symposium

From Drug Delivery to Tissue Engineering:
Bioengineering and its Impact on Human Health

    Opening Remarks
    Jeffrey S. Flier, MD, Dean of the Faculty of Medicine, Harvard University

    Award Lectures

    Bioengineering and Its Impact on Cardiac Surgery
    Alain F. Carpentier, MD, PhD, Chief of Cardiovascular Surgery, Hôptial Européen Georges-Pompidou

    Biomaterials and Biotechnology: From the Development of Controlled Drug Delivery Systems to the Foundation of Tissue Engineering
    Robert S. Langer Jr., ScD, David H. Koch Institute Professor, Massachusetts Institute of Technology

    Invited Lectures

    Moderated by
    Don Ingber, MD, PhD, Director, Wyss Institute for Biologically Inspired Engineering

    Infection-Mimicking Polymers as a Cancer Vaccine
    David J. Mooney, PhD, School of Applied Engineering and Wyss Institute for Biologically Inspired Engineering, Harvard University

    Cancer Nanotechnology to Hepatic Tissue Engineering
    Sangeeta Bhatia, MD, PhD, Health Sciences and Technology and Electrical Engineering and Computer Science, Massachusetts Institute of Technology

    DNA Nanostructures as Building Blocks for Future Therapeutics
    William Shih, PhD, Dana-Farber Cancer Institute, Harvard Medical School, and Wyss Institute for Biologically Inspired Engineering, Harvard University

2010 Prize Symposium

Video is available from this program.

    Welcome
    Jeffrey S. Flier, MD, Dean of the Faculty of Medicine, Harvard Medical School
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    Opening Remarks
    David T. Scadden, MD, Harvard and Massachusetts General Hospital
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    Therapy with Cultured Cells, Looking Back
    Howard Green, MD, the George Higginson Professor of Cell Biology at HMS and winner of the 2010 Warren Alpert Foundation Prize for developing methodologies for the expansion and differentiation of human keratinocyte stem cells for permanent skin restoration in victims of extensive burns
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    Skin Stem Cells and Morphogenesis
    Elaine Fuchs, PhD, Howard Hughes Medical Institute and Rockefeller University
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    Disease Modeling with Pluripotent Stem Cells
    George Q. Daley, MD, PhD, Howard Hughes Medical Institute, HMS, Children’s Hospital Boston and Dana-Farber Cancer Institute
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    Understanding Cellular Reprogramming
    Konrad Hochedlinger, PhD, Howard Hughes Medical Institute, Harvard and Massachusetts General Hospital
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    Reflections on Embryonic Stem Cells
    Howard Green, MD
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Congratulations to the recipients of the 2013 Warren Alpert Foundation Prize
David Botstein of Princeton University, and Ronald W. Davis and David S. Hogness, both of Stanford University School of Medicine, are the recipients of the 2013 Warren Alpert Foundation Prize for their seminal contributions to concepts and methods of creating a genetic map in the human, and of positional cloning, leading to the identification of thousands of human disease genes and ushering in the era of human genetics. Read about the recipients.

Nominations are closed for 2014
Please check back in June for information on nominations for the 2015 Warren Alpert Foundation Prize

2013 Warren Alpert Foundation Prize Symposium
A scientific symposium was held honoring this year's winner on October 3, 2013. View details.



©2012 Warren Alpert Foundation. All Rights Reserved.