Cardiometabolic Medicines From the Gut: The Glucagon-Like Peptide Story

To view a recording of the 2020 Warren Alpert Prize Symposium. click link below
View Recording

2020 Warren Alpert Foundation Prize Virtual Symposium

In honor of Daniel Drucker, Joel Habener, Jens Juul Holst for identifying the family of Glucagon-Like Peptides through studies extending from cells to humans, culminating in the development of these peptides and related pathway-modifiers as important new classes of therapeutic agents for treating diabetes, obesity and short bowel syndrome.

Daniel J. Drucker

Daniel J. Drucker | 2020 Recipient

Dr. Daniel J. Drucker is an Endocrinologist and Professor of Medicine in the Division of Endocrinology, Department of Medicine, University of Toronto. Dr. Drucker received training in Internal Medicine and Endocrinology from the Johns Hopkins Hospital in Baltimore and the Toronto General Hospital, University of Toronto and completed a research fellowship in Molecular Endocrinology (1984-87) at the Massachusetts General Hospital. Dr. Drucker established his own laboratory research program in 1987 in Toronto.

A pioneer in diabetes treatment, Dr. Drucker's work has provided important insights leading to the development of new drugs for the treatment of Type 2 diabetes. Currently, his laboratory at the Lunenfeld-Tanenbaum focuses on understanding the molecular biology and physiology of glucagon-like peptides.

He is the recipient of the 2009 Clinical Investigator Award from The Endocrine Society,  2011 Oon International Award for Preventive Medicine, Cambridge University School of Medicine, 2014 Banting Medal for Scientific Achievement, American Diabetes Association, 2014 Manpei Suzuki International Prize for Diabetes Research, Manpei Suzuki Foundation, 2015 Elected Fellow of the Royal Society of London, 2015 Appointed Officer of the Order of Canada.

Joel Habener

Joel Habener | 2020 Recipient

Joel Francis Habener, M.D. received his B.S. degree Cum Laude in 1960 from the University of Redlands, Redlands, California and in 1965 his M.D degree from the University of California School of Medicine, Los Angeles, California.  Dr. Habener is Professor of Medicine at the Harvard Medical School, Associate Physician at the Massachusetts General Hospital, and a former Investigator with the Howard Hughes Medical Institute.  He is the Director of the Laboratory of Molecular Endocrinology in the Department of Medicine at the Massachusetts General Hospital.

His research interests are in the fields of obesity, diabetes, and metabolism with a focus on the interactions of growth factors and morphogens on the expression of transcription factors during development and in the regulation of hormone production by endocrine organs of the body.  He has authored over 450 research articles, books and reviews on these subjects.  He is a discoverer of the insulinotropic hormone glucagon-like peptide-1, cyclic AMP response element binding protein, the pancreas duodenal homeodomain protein, and the existence of multipotent stem cells in the pancreas. Dr. Habener holds several patents on these discoveries. Dr. Habener’s discoveries contributed to the development of glucagon-like peptide-1, currently successfully in use as a treatment for diabetes.

Dr. Habener is a member of several editorial boards of scientific journals and has served on many advisory committees of pharmaceutical companies and the National Institutes of Health.  He is the recipient of several awards, including the Edwin B. Astwood Award, Robert H. Williams Distinguished Leadership Award, and Outstanding Mentorship Lauriet Award by the Endocrine Society, and the Harrington Prize for Innovation in Medicine (shared) from the American Society of Clinical Investigation and the Harrington Discovery Institute.

Jens Juul Holst

Jens Juul Holst | 2020 Recipient

Jens Juul Holst is a professor at the Department of Biomedical Sciences and at the same time affiliated with the Novo Nordisk Foundation Center for Basic Metabolic Research. Jens Juul Holst's research concentrates on appetite regulation and hormones that regulate metabolism (digestion).

Jens is head of a research group that focuses on obesity and type 2 diabetes, especially with the aim of mapping hormonal disorders and the possibilities of treatment based on hormones. He has also taken part in developing a wide range of drugs used in treatment of type 2 diabetes.

He is the recipient of several prizes including the 2017  UCPH Innovation Prize, 2017 The Harrington Prize for Innovation in Medicine, 2015 The Nordic Fernström Prize, 2013 The Anders Jahre Senior Medical Prize, 2013 The Marie and August Krogh Award, 2012 The European Medal of the Society for Endocrinology, 2010 The Bagger-Sørensen Award (DKK 500,000), and 2009 KFJ prize of the Faculty of Health Sciences at the University of Copenhagen.

Jens is co-founder of start-ups, including Antag Therapeutics and Bainen Biotech.

Symposium Program

Each year the recipient(s) of the Warren Alpert Foundation Prize are recognized at a scientific symposium hosted by Harvard Medical School.

Featured Speakers include:

Fiona Gribble, DPhil, BM, BCh

Professor of Endocrine Physiology WT-MRC Institute of Metabolic Science University of Cambridge

Gut endocrine cells - chemosensors of the postprandial state

Jens Juul Holst, MD, DMSc

Professor, Department of Biomedical Sciences and Group Leader Translational Metabolic Physiology, Novo Nordisk Foundation Center for Basic Metabolic Research University of Copenhagen

GLP-1 in humans

Joel Habener, MD

Professor of Medicine, Harvard Medical School Director of the Laboratory of Molecular Endocrinology, Massachusetts General Hospital

Glucagon-like Peptide-1: Discovery, Structure, Activity

Daniel Drucker, MD

Senior Scientist, the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada, Professor of Medicine, University of Toronto

The protean peptide GLP-1; From metabolism to inflammation and cardioprotection

Matthias H. Tschöp, MD

Alexander von Humboldt Professor, Technical University of Munich Chief Executive Officer and Scientific Director, Helmholtz Center Munich

Glucagon-like polyagonists - discovery, mechanism and clinical translation

Sign up to receive updates

Sign up to receive updates

Past Symposia

For questions about the prize, please contact us.

Contact Us
To think that I would share this prize with Joan Steitz, someone who I have respected and admired for decades, is something I could never have imagined for much of my scientific career. I spent many years hoping that our hypotheses were correct, although I couldn’t think of another way to interpret our data, and we were very careful in our analyses. Right now, I am simply thrilled. It feel enormous gratitude to be recognized by my peers in this way.
- Lynne Maquat

Lynne Maquat | 2021 Recipient

Dr. Lynne Maquat is the J. Lowell Orbison Endowed Chair, Professor of Biochemistry & Biophysics who holds concomitant appointments in Pediatrics and in Oncology, Founding Director of the Center for RNA Biology, and Founding Chair of Graduate Women in Science at the University of Rochester, Rochester, NY. After obtaining her PhD in Biochemistry from the University of Wisconsin-Madison and undertaking post-doctoral work at the McArdle Laboratory for Cancer Research, she joined Roswell Park Cancer Institute before moving to the University of Rochester. Dr. Maquat’s research focuses on the molecular basis of human diseases, with particular interest in mechanisms of mRNA decay. Dr. Maquat discovered nonsense-mediated mRNA decay (NMD) in human diseases in 1981 and, subsequently, the exon-junction complex (EJC) and how the EJC marks mRNAs for a quality-control “pioneer” round of protein synthesis. She also discovered Staufen-mediated mRNA decay, which mechanistically competes with NMD and, by so doing, new roles for short interspersed elements and long non-coding RNAs. Additionally, she has defined a new mechanism by which microRNAs are degraded, thereby regulating mRNAs so as to promote the cell cycle.

Maquat is an elected Fellow of the American Association for the Advancement of Science (2006); an elected Member of the American Academy of Arts & Sciences (2006), the National Academy of Sciences (2011), and the National Academy of Medicine (2017); and a Batsheva de Rothschild Fellow of the Israel Academy of Sciences & Humanities (2012-3). She received the William C. Rose Award from the American Society for Biochemistry & Molecular Biology (2014), a Canada Gairdner International Award (2015), the international RNA Society Lifetime Achievement Award in Service (2010) and in Science (2017), the FASEB Excellence in Science Award (2018), the Vanderbilt Prize in Biomedical Science (2017), the Wiley Prize in Biomedical Sciences (2018), the International Union of Biochemistry and Molecular Biology Medal (2019), and the Wolf Prize in Medicine (2021). Maquat is well-known for her efforts to promote women in science.

 View Past Recipients